Ronald Burrell had 20 points and 12 rebounds and EWE Baskets shot very well at the free-throw line in a 77-69 win over BK Ventspils in Germany.
Unbeaten in the Regular Season, EWE Baskets prevailed in the Group I clash for the seventh consecutive game in the competition.
Predrag Krunic's team got a defensive lift from Kenny Hasbrouck, who had five of the team's eight steals.
He and Ricky Paulding scored 15 points apiece.
EWE Baskets made 19 of their 22 free-throws compared to Ventspils' 12 of 22 effort.
The home side led from start to finish but were only on top 30-27 at half-time.
After Paulding began the second half with a lay-up, Ventspils pulled to within 32-30 on a three-pointer from Arturs Berzins.
The hosts then hit their Latvian opponents with a flurry of blows they would not recover from.
Hasbrouck drilled a three-pointer and made a lay-up before Adam Chubb scored down low.
Burrell followed with a jumper and drew a foul.
He sank the free-throw for the three-point play to cap the 10-0 run.
EWE Baskets stretched the advantage to 61-39 late in the third quarter.
They ended up outscoring the visitors, 31-15, in the frame.
Ventspils, mindful that goal differential could be a determining factor if a tie-breaker is needed at the end of Last 16 play, battled and reduced the deficit to eight by the end of the contest.
The 20-year-old Latvia international center Martins Meiers had 23 points and seven rebounds in defeat.