|Amaya Veldemoro had 15 points and 8 rebounds|
The Spanish streaked out to a 38-18 half-time lead and cruised to a 71-47 win.
Amaya Valdemoro, who opended her account in this tournament with 18 points in Friday's win over Belgium, had the hot hand again with a game-high 15 points.
Included in the performance of the former WNBA champion with the Houston Comets were two three-pointers from five attempts. She also had eight rebounds and three steals.
Alena Kovacova and Andrea Belanska each scored 11 points for the Slovaks, who were a woeful 13 of 54 from the floor.
Spain outrebounded the Slovaks 47-39.