|Birsel Vardarli and Ivana Matovic are yet to taste defeat in this season's EuroLeague Women|
The Turkish juggernauts made it 12 victories in as many games after a contest when they had plenty to spare and enough left in the tank to stroll towards the second phase.
With top seed in the play-offs already assured, Roberto Iniguez and his players had little difficulty in despatching the struggling Czech team, managing to lead from tip to buzzer.
With French center Isabelle Yacoubou not stepping out, Ivana Matovic grabbed the frontcourt spotlight and came up with her best display of the campaign so far.
She conjured up 18 points after sinking six of seven from inside the paint and also adding eight rebounds in a great night of work.
With the usually reliable Alena Hanusova having an off night for Brno, it proved tough for the away team to get any foothold in the game.
Tereza Peckova tried her best to inspire a revival after her side fell down by double-digits and finished with 19 points, whilst team-mates Danielle Hamilton and Veronika Vlkova shared 26 points, but it wasn't enough.
Once ahead, Fenerbahce kept Brno at arms' length with ease and marched onwards, still yet to taste defeat in the competition.
Roberto Iniguez, Fenerbahçe Coach:
"We are happy to be first in the [overall] ranking. We played well. The play-offs will be a difficult time to concentrate. Congratulations to my players."
Olcay Cakır, Fenerbahce:
"We are happy . Now we will work much harder before the play offs."
Jan Bobrovsky, Imos Brno coach:
"We were not as strong as Fenerbahçe . I am upset about that loss. We are now looking forward to our league. We are upset. We will find out where it all went wrong [in EuroLeague Women].
Anna Jurcenkova, Imos Brno:
"I am upset. Good luck to all teams in the play offs."