Sparta&K Moscow Region Vidnoje clinched a 67-55 win at Good Angels Kosice on Wednesday night.
Seimone Augustus poured in 19 points for the Russian team.
The outcome has left both sides with 3-2 records in Group C.
Sparta&K went in front to stay when Slovenian youngster Nika Baric pulled up for a jump shot to make it 15-14 for the visitors.
Augustus then drew a foul from Erin Lawless and made two free-throws before making a jumper to stretch the lead to 19-14.
By half-time, the advantage was 38-30 and Candice Dupree, facing her former team, was the first to score at the start of the second half to make it a 10-point game.
Marina Kuzina's jumper extended the lead to 56-42 by the end of the third quarter and Sparta&K coasted home in the fourth.
Dupree had 12 points and Becky Hammon 11 for Sparta&K.
Danielle McCray led the Slovaks with a game-high 20 points.
Sparta&K Moscow Region Head Coach Pokey Chatman
"We knew, that it will be a tough match. We knew, that it will be battle of defense. We played solid defense during the whole game. We are pleased with the win, but now we are looking forward because more difficult matches await our team."
Good Angels Košice Head Coach Štefan Svitek
"It was a very difficult game, a game decided by the individual strength of the opponent's players. Very good game by Augustus and Dupree. It was a game of defense, in which we had a little bit of shooting pitch and at the end we missed these points."
Sparta&K Moscow Region player Candice Dupree
"It was a very good game for us. I thought, we really want to win and we knew, that Good Angels had before this match only one loss and they were on top of the group. This game was not about offense and therefore our good defense was most important.
Good Angels Košice player Danielle McCray
"We tried to play hard together, in the beginning we played as we were supposed to. Sparta&K was a very hard oponent, their players are very versatile, they made very good job on defense, were agressive on the ball and overall they were better tonight."