Ros Casares scored 11 unanswered points at the start of the game and blew away Bourges Basket on Tuesday evening.
In the second week of the EuroLeague Women, the Spanish giants underlined their status as the team to beat in Group B with a 74-47 triumph.
With center Nicky Anosike, who has joined the club late after having arthroscopic knee surgery in late August, still not playing, Ros marched to a decisive win using just 10 players.
Rebekkah Brunson had 14 of her game-high 19 points in the first half.
The American also led all players in the contest with 14 rebounds.
Ros Casares hit all three of their first-half three-balls in their opening spurt.
Linda Frohlich buried the first and following a basket from Brunson, Edwige Lawson-Wade drilled back-to-back three-pointers for the 11-0 advantage.
Bourges stayed within striking distance until a few minutes into the second quarter when Ros lowered the boom and stretched a 24-15 advantage to 41-18.
Defense sparked the home side in that surge.
Laia Palau picked off a pass by Maja Miljkovic and fed Cindy Lima, who made a lay-up.
Then just seconds after Bourges' Catherine Joens was called for travelling, Ros' Marta Fernandez drew a foul and made two free-throws.
Jordi Fernandez's team was never under threat in the second half.
Palau scored just three points but had five assists and three steals.
Marta Fernandez finished with 15 points and Lawson-Wade had eight.
While Ros improved to 2-0, Bourges slipped to 1-1.