One week after falling to Fenerbahce at home, Gundars Vetra's side defeated visiting Gospic Croatia, 77-63.
Russian national team star Maria Stepanova had 20 points and six rebounds for UMMC, who improved to 5-1.
The setback for Gospic Croatia (0-6) has left them as the only side in the competition without a victory.
Stepanova had eight points and Olga Arteshina six as Russia threatened to blow the game wide open in the opening seven minutes when they took a 22-2 lead.
Gospic finished the quarter with a 10-0 run, though, and then closed to within 29-21 early in the second frame after a three-pointer from Iva Badanjak.
Ivana Jurcevic's three-ball reduced the arrears to 33-26 with 4:19 to go in the first half.
That was as close as they would get.
UMMC kept them at arm's length with Crystal Langhorne's bucket stretching the advantage to 13 at half-time.
After the restart, Cappie Pondexter scored six points in an 8-0 spurt for a 52-31 Ekaterinburg stranglehold and they stayed in command the rest of the way.
UMMC led by as many as 23 before easing to a 14-point win.
"Tonight we've played a very good game. Before we had had fifty-one-hours trip, and the players were terribly tired. The home team - Ekaterinburg - is an excellent team. They have seven foreign superstars. In the first seven minutes we played badly, and lost sixteen points, but later we improved our play."
Head Coach of UMMC Gundars Vetra:
"It took our opponent team very long time to arrive in Ekaterinburg. Probably, for this reason our players were relaxed, and lacked the needed concentration. However, it should be noted, that we started very well, dictated pace, but the following substitutions were not very successful. We lowered our speed, and the game became tough."