Evanthia Maltsi had 31 points and Lindsay Whalen 24 as ZVVZ USK Prague topped MKB Euroleasing 98-75 in a scoring-fest in the Czech capital.
Maltsi made four of seven (57.1%) from three-point range and six of 11 (54.5%) from two-point range in an outstanding performance, while Whalen was even more efficient, making three of five (60%) from long-range and five of nine (55.5%) from around the basket.
Marketa Bednarova also scored in double figures with 12 points.
But despite the offensive fireworks, the key to the game for Prague was on defence, where 30 of their 38 rebounds came to restrict MKB's opportunities.
Even so, Dora Horti got 21 points for the visitors, and Amber Holt added 18 while Katalin Honti had 12.
Prague improve to 3-2 in Group C, while MKB slip to 2-3.