Halcon Avenida led from start to finish and thrashed hosts ESB Lille Metropole 97-72 in EuroLeague Women Group B.
Chasing a second-place finish in the pool, Avenida brushed aside their French opponents.
Sancho Lyttle poured in 11 of her 13 points in the first quarter as the Salamanca team built a 32-17 advantage.
When Silvia Dominguez's three-pointer went in right before half-time, Avenida had a 52-34 stranglehold on proceedings.
The Spaniards, who suffered a narrow defeat to Ros Casares in the Copa de la Reina final on Sunday, cruised the rest of the way.
Anke De Mondt scored 24 points for Avenida, who also got five from new signing Emilija Podrug.
The Spanish outfit improved to 7-2.
Lady Comfort scored 16 points for ESB in defeat.
The French team lost for the eighth time in nine games.