With UMMC Ekaterinburg having won their game earlier in the day against Union Hainaut to improve to 9-1 and clinch first place, Ros knew they would finish second in the standings.
Isma Canto's team only led 46-43 two minutes into the second half but then reeled off 11 straight points to take command.
Delisha Milton-Jones followed baskets by Roneeka Hodges and Jana Vesela with a three-pointer, and after Erika De Souza made two free throws, Milton-Jones added two from the line for a 57-43 advantage.
The Spanish giants pulled away for a decisive win in the fourth quarter.
Milton-Jones finished with 20 points to lead Ros while Luca Ivankovic had 21 in defeat.
Ros Casares won the battle of the boards, 48-34.
Jolly started well this season but finished dead last in the group at 2-8.