The French improved to a perfect 3-0 with the success, rendering their game against Finland on Monday meaningless since neither the Finns (0-2) nor Italy (1-2) can overtake them.
They will now meet the top team of the other group in a home-and-away leg to determine the last team to play at the EuroBasket.
Bosnia and Herzegovina improved to 3-0 in Group A with a 73-61 win over Portugal on Friday.
France were pushed hard in their opening two wins over the Italians and Finns but they romped to victory in their second win over the Azzurri.
With Nicolas Batum overcoming a shoulder problem to play, the French had all the important players they needed in their squad and they were ruthless.
Florent Pietrus scored all eight of his points in the first quarter, two on a dunk with 2:39 to go in the period for a 19-5 lead.
In fact, it marked the third consecutive time that France had scored with a dunk after slams by Pietrus and Batum.
The lead ballooned to 28-11 when Alain Koffi made two free-throws.
Though Italy managed to claw the deficit back to 32-21, France took a 41-27 lead to the break.
Batum had 12 points and Parker 11 by half-time.
After the interval, France's lead remained in double digits as they cruised to a decisive victory.
Batum finished with 18 points and eight rebounds and Ronny Turiaf scored 14 points with five boards.
Pietrus walked off the court as his team's leading rebounder with nine.
France out-rebounded Italy 38-27.
Italy must now go back to the drawing board.
They still have a game remaining against Finland that has no ramifications on the EuroBasket.
Marco Belinelli scored 19 points to lead the Azzurri with Jacopo Giachetti contributing 13 and Matteo Soragna 11.
Italy's Andrea Bargnani was held to just five points and five rebounds.