Fenerbahce held off a late fightback from Phard Napoli to claim a narrow 77-73 victory and take their record to 4-2 in EuroLeague Women Group A.
Cappie Pondexter was the leading scorer for the Turkish visitors with 29 points while Tammy Sutton-Brown added 16 and six rebounds.
Kedra Holland-Corn led Napoli's cause with 24 points but it was not enough in the end.
The first quarter was a tight affair in which neither side could break free.
Pondexter scored three of three from outside the arc while Holland-Corn responded with four free-throws in a period which Phard edged 22-21.
A 5-0 run at the start of the second quarter helped the Turkish side gain the upper hand however, with eight points from Sutton Brown, including four of four from the charity stripe, steering them to a 43-35 advantage at half-time.
Fenerbahce maintained that lead throughout the third quarter to take a 62-53 lead into the final 10 minutes, but hosts Napoli came back fighting in the fourth.
Led by Holland-Corn, Phard closed within three points of their opponents at one stage until four free-throws from Pondexter ensured Fenerbahce claimed the win.