|Italy international Laura Macchi led the surprise charge for Beretta-Famila with 19 points|
Beretta-Famila Schio travelled to Spain and upset defending EuroLeague Women champions Perfumerias Avenida 67-59 in their opening Round 2 clash.
Italian veteran Laura Macchi had 19 points to pace Schio, who can now reach the Final Eight with a win at home on Friday.
The Salamanca fans never give up but even they were stunned late in the first half, when Schio had a 37-20 lead.
Four Liron Cohen free-throws sandwiched a jump shot by Janel McCarville to push the Beretta-Famila advantage to 17.
Erika De Souza and Dewanna Bonner each made two free-throws at the end of the second quarter for Avenida and the hosts went to half-time staring at a 37-24 deficit.
The scoring run reached six when Marta Fernandez, who had 18 points, buried a jumper at the start of the third to leave Schio in front, 37-36.
De Souza's two free-throws reduced the arrears to 43-36 with 4:11 to go in the third quarter, but Schio maintained a comfortable lead as first McCarville hit a jumper and then recent signing Ivana Jalcova drilled a three-pointer to make it 48-36 in favor of the Italians.
Avenida got to within five points early in the fourth quarter after a basket by Fernandez but Cohen nailed a three-pointer for Schio and the Italians held on for an impressive road triumph.
Lucas Mondelo's team stayed in the game thanks to its free-throw shooting.
Avenida made 23 of 24 free-throws.
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Beretta-Famila Head Coach Maurizio Lasi
"We started very well, in the way we practised before coming here, and doing an intensive game under the basket. Anyway it is only the first game, and we hope the next one will be very tough."
Perfumerias Avenida Head Coach Lucas Mondelo
"We made a lot of mistakes, especially under the basket and this will be the clue for the next game. We will be in Italy to win because if they got to win here, on our court, we will be able to do the same there."
Beretta-Famila player Laura Macchi
"We took from this game the confidence we need to face the next one. But we must not forget that it is only the first game and it is not over, because there are two more and we have to be very concentrated."
Perfumerías Avenida player Marta Fernández
"We suffered from anxiety and we weren´t able to control our feelings. The main problem for me was in the rebounds, because we made a lot of mistakes being unable to control them."