Besiktas Cola Turka led by 11 points late in the second quarter but resilient Halcon Avenida held their nerve and battled back for an impressive road win in Istanbul on Wednesday.
The Spanish outfit prevailed 67-61 to improve to 2-1 on the young EuroLeague Women season.
Last week, the team edged Russian outfit Nadezhda by just three points.
Belgium international Anke De Mondt hit the game-winning three-pointer in that home win over Nadezhda and against Besiktas, she hit another big shot.
Her three-ball snapped a 52-52 tie with 6:13 remaining to put the Salamanca team in front for good.
Donnette Snow, who had a very impressive night with 16 rebounds, followed De Mondt's three with a basket for two of her 13 points.
Le'Coe Louise Willingham led Avenida with 15 points while young Silvia Dominguez scored 13 and grabbed six rebounds for Avenida.
Latvia international Gunta Basko also had 13 points and four assists but turned the ball over five times.
Besiktas, who fell to 1-2, got a game-high 17 points from Shay Doron.