Halcon Avenida led by as many as 10 points in the first half and seven after the intermission, but lost to CSKA Moscow on Friday to exit the EuroLeague Women play-offs.
CSKA completed a 2-0 eighth-finals series victory to remain undefeated in all competitions and will now play in the last eight.
CSKA Moscow beat Halcon Avenida 83-64 to remain undefeated in all competitions, but the Spanish team can return home for Game Two later this week with their heads held high after a brave performance in Russia.
Ann Wauters led five CSKA players in double figures with 21 points, while Isa Sanchez paced the Salamanca club with 14.
UMMC Ekaterinburg came back from an 11-point deficit at half-time to record a 96-76 victory at Halcon Avenida.
Poland's Agnieszka Bibrzycka was five of seven from three-point range and led Ekaterinburg with 22 points as the Russian outfit clinched its ninth victory in 10 Group B games.
Halcon Avenida stayed on track for a place in the eighth-finals of the EuroLeague Women with an 80-73 win over ZVVZ Prague.
The victory was the Spanish club's fourth in Group B and leaves them one game clear of Jolly JBS Sibenik, who won on the road on Wednesday at Wisla Can-Pack Krakow.
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