In a remake of last year's final, Kayseri suffered a 77-64 overtime defeat at reigning champions Dynamo Kursk, but advanced thanks to their 15-point victory in the first leg, prevailing 165-163 on aggregate.
The second Semi-Final will see an all-Russian clash between Chevakata Vologda and Dynamo Moscow, after they eliminated the last French clubs left in the competition.
Chevakata confirmed their 79-51 first-leg victory with a 66-45 away win at Hainaut Basket, while Dynamo Moscow won both quarter-final legs against Basket Lattes Montpellier Agglomeration, 159-135 on aggregate.
The Semi-Finals will be contested over two legs. The first games will be played on 7 February with the return legs scheduled for 14 February.
MBK Ruzomberok (SVK) - Kayseri Kaski spor (TUR)
Dynamo Moscow (RUS) - Chevakata (RUS)