The win has given the Perm side a 3-1 record while dropping the French club to 2-2.
Alexey Surovtsev and Vanja Plisnic combined for 46 points for Ural Great - more than half of the team's output.
The Russian team opened up a 39-25 lead with 4:14 remaining in the first half when Surovtsev tipped in Jumaine Jones' miss from three-point range.
That basket gave Surovtsev 12 points for the first half.
French club Hyeres responded, however, with an 18-5 run bridging the second and third quarters to trail 44-43.
That surge was capped by Pierre Pierce's jump shot with 8:27 to go in the third quarter which took his tally to 13.
The basket woke up Ural Great because they reeled off the next nine points, all of them scored by either Plisnic or Sergey Chernov, for a 53-43 lead with 4:48 to go in the third frame.
This time, Roman Dvinyaninov's men pressed home the advantage.
They took a 59-45 lead with 2:35 to go in the quarter and stretched that to 79-55 with 6:37 to go in the game.
The hosts eased up, and Hyeres managed to out-score them 21-5 the rest of the way to lose by just eight.
Plisnic and Surovtsev each poured in 23 points for Ural Great while Hrvoje Perincic had 20 and both Pierce and Austin Nichols 16 apiece.